Open access
Jul 2026
Cross-genus analysis reveals architecturally programmed sgRNA synthesis patterns in coronaviruses.
Coronaviruses employ discontinuous transcription to produce canonical subgenomic RNAs (sgRNAs) essential for gene expression. Although TRS-dependent template switching mechanism has been proposed, its structural basis remains poorly defined, and the functional significance of abundant non-canonical sgRNAs persists as a...
Zi Wen, Lei Chen, Dehua Luo et al.
· Molecular Systems Biology · 0 citations