Author

Yuxiao Zhang

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Open access Aug 2026

Myeloma-derived exosomal circ_0002724 promotes osteoclastogenesis through a miR-4753-3p/IFIT1 and RANK axis in myeloma bone disease

Background Myeloma bone disease (MBD) is driven by excessive osteoclast activation and progressive bone destruction, but the role of exosomal circular RNAs (circRNAs) from myeloma cells remains unclear. Methods Exosomes from U266 and MM1S cells were isolated and used to treat THP-1 cells. Osteoclast differentiation was...

N. Yi, Muyun Wu, Xiao-Jie Ma et al. · Frontiers in Oncology · 0 citations

Open access Jul 2026

A three-gene signature correlated with MAPK/ERK activation characterizes acquired resistance to EGFR-tyrosine kinase inhibitors in non-small cell lung cancer

It is suggested that MAPK/ERK signaling contributes to the transition from adaptive tolerance to stable resistance to afatinib and highlight a tractable therapeutic vulnerability for overcoming resistance to tyrosine kinase inhibitors in NSCLC.

Chang-Tai Qin, Wei Zhang, Dongfang Tang et al. · Oncology Letters · 0 citations