Author

Yuxuan Deng

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Sep 2026

H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids.

Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...

Lu-Yang Xie, Zhuan-Xin Jiang, Hang Zhou et al. · Cell Stem Cell · 1 citation

Open access Sep 2026

Synergistic antitumor effect of HMGB2 targeting combined with MDM2 inhibitor in diffuse intrinsic pontine glioma therapy

Diffuse intrinsic pontine glioma (DIPG) is a brain malignancy in children with a dismal prognosis. The high mobility group box 2 (HMGB2) is a member of the HMGB family of chromatin-associated proteins, and is identified as a potential oncogene in various cancers. However, the effects of HMGB2 in DIPG remains unclear. I...

Bo-Chao Zhang, Yuxuan Deng, Lu-Yang Xie et al. · Frontiers in Oncology · 0 citations

Open access Jul 2026

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

An association between reduced P53 function and increased expression of the epigenetic regulator TET1 in GBM models is identified, suggesting that TET1 may serve as a potential mediator of therapy resistance and a promising therapeutic target in TP53mut GBM.

Zhuonan Pu, Jinqiu Liu, Yuxuan Deng et al. · Advancement of science · 0 citations