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Z. A. Laghari

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Open access Sep 2026

STN1 upregulation promotes PARPi resistance in BRCA2-deficient cancer cells via replication fork protection and suppression of ssDNA gap formation

It is suggested that elevated STN1 levels can partially compensate for BRCA2 loss by stabilizing stalled replication forks and limiting ssDNA gap accumulation, which is a major determinant of PARPi sensitivity in BRCA2-deficient cells.

Z. A. Laghari, Na Li, Serdar Gayybov et al. · 0 citations

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