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Open access Oct 2026

Contribution of cerebrovascular lesions to neurodegeneration and cognitive decline

Introduction: Cerebral small vessel disease (CSVD) lesions, including white matter hyperintensities (WMHs), lacunar infarcts, cerebral microbleeds (CMBs), and enlarged perivascular spaces (PVSs) are associated with increased risk of dementia. In this study, we aimed to examine their associations with risk factors, neur...

Z. Chen, S. Raeesi, A. Metz et al. · 0 citations
Open access Sep 2026

Data-driven subtypes of Alzheimer’s Disease: A multicohort study

These findings, replicated in four diverse and independent datasets, support imaging-based subtyping as a scalable and clinically translatable approach for capturing heterogeneity in AD pathophysiology and associated cognitive trajectories.

A. Metz, Cassandra Polizzi, R. Moqadam et al. · 0 citations

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