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Author

Z. Ellederová

2 papers indexed here

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Open access Sep 2026

Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model

The study describes the generation of a humanized pig model carrying an inducible phospholamban R14del mutation for cardiomyopathy modeling and demonstrates Cre-based activation strategies as efficient alternatives to germline Cre-driver lines in large animals.

Petra Runa-Vochozkova, M. Vaškovičová, J. Cambra et al. · 0 citations
Open access Aug 2026

Generation of isogenic gene-corrected cell lines from a USH2A-RP patient-derived iPS cell line.

Comparative studies using induced pluripotent stem cells (iPSCs) from patients with those from healthy individuals as controls are flawed by genetic background contribution to disease phenotype. Here, we used precise gene editing to generate gene-corrected isogenic control lines for a single pathogenic variant in the U...

Verónica del Buey Furió, Belén García-Bohórquez, G. García-García et al. · 0 citations

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