Author

Zoheir Guesmia

2 papers indexed here

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Open access Aug 2026

Axonopathy in Duchenne Muscular Dystrophy limits microdystrophin gene therapy efficacy

DMD is redefined as an integrated motor unit pathology, thereby underscoring the absolute necessity of implementing combined therapeutic strategies that target both the muscle and the peripheral nervous system.

Aly Bourguiba-Villeneuve, Maxime Gelin, Aurélie Fail et al. · bioRxiv · 0 citations

Jul 2026

LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathy.

This work provides a paradigm for connecting gene-specific nuclear defects to mitochondrial dysfunction in inherited cardiomyopathies and highlights the MCU complex as a potential therapeutic target in LMNA-related cardiomyopathy.

M. Seguret, C. Jouve, A. Ruiz-Velasco et al. · Cardiovascular Research · 1 citation