Author

Z. Kaplancıklı

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Open access Oct 2026

Design and Synthesis of New Thiazole Derivatives for Alzheimer’s Disease Therapy as a Potential Cholinesterase Inhibitor; Toxicity Prediction and Molecular Docking Studies and Biological Evaluation

In this study, thiazole derivatives 13–23 were synthesized as novel cholinesterase inhibitors. Their structures were elucidated using 1H-NMR, 13C-NMR, and elemental analysis techniques. The binding positions and efficiencies of the designed compounds on the enzyme were investigated through molecular docking studies, an...

Mesut Işık, Gresa Halimi Syla, Abdüllatif Karakaya et al. · Molecules · 0 citations

Open access Sep 2026

Design, Synthesis, In Vitro and In Silico Evaluation of Triazole–Benzimidazole Hybrid Derivatives as Potential Inhibitors of EGFR, EGFR-L858R, and EGFR-L858R/T790M

Epidermal growth factor receptor (EGFR) has become one of the most important molecular targets for the development of anticancer agents because of its critical role in regulating cell proliferation, differentiation, and survival. In the present study, a novel series of benzimidazole–triazole derivatives were designed b...

Harun Uslu, Arzu Hıdır, Esra Yumuşak et al. · Molecules · 0 citations

Open access Sep 2026

Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors

Findings identify trimetazidine‐derived hydrazide‐hydrazones as a promising chemotype for the development of selective AChE inhibitors and provide a basis for further optimization and advanced biological validation.

Muhammed Oğuzhan Doğan, B. Özkan, A. B. Karaduman et al. · Drug development research (P... · 0 citations

Open access Jul 2026

Design, Synthesis, In Silico ADME, Toxicity Prediction and Molecular Docking Studies of Benzimidazole-Oxadiazole Derivatives for α-Glucosidase and Aldose Reductase Pathways as Potent Anti-Diabetic Agents

Overall, the newly synthesized compounds demonstrated pronounced AR inhibitory activity and notable α-GLY inhibition and may therefore be considered potential candidates for further investigation as anti-diabetic agents.

Mesut Işık, Abdüllatif Karakaya, U. A. Çevi̇k et al. · Molecules · 0 citations