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Author

Z. Karányi

2 papers indexed here

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Open access Oct 2026

Pegvisomant in severe, treatment-resistant thyroid eye disease: a case report

Teprotumumab, a monoclonal antibody against the IGF1 receptor, has proven effective in the treatment of thyroid eye disease (TED). Pegvisomant reduces IGF1 levels through selective inhibition of growth hormone receptors. Here, we present a hypothesis-generating case of a 69-year-old patient with progressive TED. Pegvis...

Laura Koroskenyi, Noémi Szkibák, Z. Steiber et al. · 0 citations
Open access Jul 2026

TOP1MT rs2293925 is an enhancer-active regulatory SNP that shapes mitochondrial R-loop dynamics.

Data support a dual-effect model in which rs2293925 increases TOP1MT expression and is associated with altered mitochondrial R-loop dynamics, linking common genetic variation to mitochondrial nucleic acid stress in disease-relevant contexts.

Dóra Varga, Zsolt Ráduly, Beáta Boros-Oláh et al. · 0 citations

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