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Author

Z. Khan

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Open access Sep 2026

Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis.

Meningeal lymphatic vessels drain brain fluid and waste into the cervical lymph nodes, but how removing these nodes during surgery affects brain health is unknown. Retrospective analysis of cancer patients who underwent neck lymphadenectomy without chemo-radiation therapy found that up to 25% developed mild-to-severe c...

Z. Khan, Cristina C. Clement, Paula Roßmüller et al. · 0 citations
Review Open access Aug 2026

Proteostasis breakdown and aggregate diversity in aging and neurodegenerative disease

A threshold model is proposed in which the cumulative burden of oxidative PTMs, protein misfolding, and impaired clearance progressively erodes proteostasis capacity, increasing susceptibility to the emergence of selective, self-amplifying aggregates.

Z. Khan · 0 citations

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