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Open access Sep 2026

Repeated Sevoflurane Exposure Acutely Does Not Disrupt the Gut Microbiome in Young Adult Female Rats

Surgery and general anesthesia (GA) may accelerate cognitive decline, referred to as perioperative neurocognitive disorder (PND), and potentially contribute to neurodegenerative conditions such as Alzheimer’s disease. However, the underlying mechanisms, vulnerable populations, and prevention strategies remain unclear. ...

Itamar Gal, Z. Khan, Anatoly E. Martynyuk · 0 citations
Open access Sep 2026

285. Pharmacological NKCC1 inhibition prevents intergenerational microbiome and neurobehavioral abnormalities following maternal preconception TBI

Abstract Background Long-term consequences of traumatic brain injury (TBI) include dysregulated stress and inflammatory signaling and neurocognitive decline. Epidemiological evidence indicates increased psychiatric vulnerability in the offspring of parents with TBI, with greater abnormalities in sons. The mechanisms in...

Z. Khan, Ling-Sha Ju, N. Gravenstein et al. · 0 citations

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