Author

Z. Liu

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Open access Sep 2026

Dissecting shared genetic susceptibility between gastroesophageal reflux disease and psychiatric disorders beyond body mass index

Gastroesophageal reflux disease (GERD) exhibits substantial comorbidity with psychiatric disorders, yet the biological basis underlying this relationship remains unclear. Here, we integrated large-scale GWAS meta-analysis, Mendelian randomization, Genomic Structural Equation Modeling, local genetic correlation analysis...

X. Wang, Q. Zhang, Q. Wu et al. · medRxiv · 0 citations

Open access Aug 2026

Cross-trait genomic analyses implicate the ITIH3 and ITIH4 locus in the shared genetic architecture of bipolar disorder and obsessive-compulsive disorder

Background: Bipolar disorder (BIP) and obsessive-compulsive disorder (OCD) frequently co-occur and show evidence of genetic overlap, yet the specific pleiotropic loci and their functional mechanisms remain unclear. Methods: We conducted large-scale genetic analyses using GWAS summary statistics for BIP and OCD, excludi...

W. Wang, P. Ju, Z. Wen et al. · medRxiv · 0 citations