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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Z. Siprashvili

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Open access Aug 2026

Lineage master regulator and cancer-selective partner transcription factors rewire 3D genome topology for tumor-specific gene control

It is shown that p63 reorganizes 3D chromatin topology in squamous cell carcinoma through cooperation with the tumor-selective partner TF, FOXK1, which defines an epigenetic mechanism by which a lineage master TF and tumor-restricted partner TF reshape 3D chromatin structure to drive oncogenic transcription, with impli...

N. Jung, V. Lopez-Pajares, L. Donohue et al. · 0 citations

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