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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Z. Stadler

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Open access Sep 2026

Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer

SUMMARY We performed an integrated clinical and genomic analysis of over 7,000 consecutively sequenced colorectal cancer (CRC) samples to comprehensively characterize genetic drivers and metastatic tropisms of CRC. We find that genomic evolutionary changes, such as clonal mutations and oncogenic mutant allele imbalance...

Paolo Manca, H. Walch, Jierui Xu et al. · 1 citation
Open access Aug 2026

Expanding the phenotype of hereditary renal cell carcinoma syndromes: Implications for surveillance and management.

BACKGROUND Approximately 5% of renal cell carcinoma (RCC) occurs in the setting of a hereditary RCC syndrome, but accurate phenotype and cancer risk estimates remain limited by ascertainment bias in reported series. METHODS We analyzed 32,728 cancer patients who underwent paired tumor-normal sequencing with MSK-IMPAC...

M. Carlo, Andrew Schroeder, Jie Liu et al. · 0 citations

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