Accurate stratification of Hodgkin lymphoma (HL) by immunologic/histological subtypes and Epstein-Barr virus (EBV) status is essential for epidemiological and translational research, yet large-scale testing is impractical and expensive. Digital pathology models that utilize routinely used hematoxylin and eosin (H&E) wh...
Zsolt Bedőházi, Z. Sztupinszki, Ragnar P. Kristjansson et al.· Journal of Pathology Informa...· 0 citations
Background Surgical resection is the standard treatment for stage I lung adenocarcinoma, in most cases without additional systemic adjuvant treatment. A substantial proportion of stage I cases recur, with a 5-year survival rate <50%. Clinical data suggest that adjuvant treatment, including immune checkpoint inhibitor t...
O. Kilim, O. Pipek, Z. Sztupinszki et al.· Immuno-Oncology Technology· 0 citations
It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.