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Open access Oct 2026

CCT2 expression marks a translation-activated state in sporadic ALS motor neurons and is associated with functional decline

Sporadic disease accounts for about 90% of amyotrophic lateral sclerosis (ALS) cases, and its biological heterogeneity is a major contributor to the failure of trials that enroll patients under a single diagnosis. Because sporadic ALS lacks a shared genetic anchor, identifying biological signals is critical for effecti...

Priyanka Bhandary, Yi-Zhou Wang, Mohamed Omar et al. · 0 citations

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