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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Z. Yochum

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Open access Sep 2026

14 Evaluation of the Effects of the HIF-2α Inhibitor Belzutifan on T-cell–Mediated Cytotoxicity in Renal Cell Carcinoma

Abstract Background Renal cell carcinoma (RCC) is characterized by a hypoxic tumor microenvironment that recruits immunosuppressive macrophages and regulatory T cells to suppress anti-tumor immunity. Belzutifan, a hypoxia-inducible factor 2 alpha (HIF-2α) inhibitor recently approved by the FDA, significantly improves p...

S. Kashima, Katrine N. Madsen, H. Soulati et al. · 0 citations
Open access Sep 2026

50 Tumor–Myeloid Multicellular Programs Reveal ECM-Associated Macrophage Polarization in ccRCC

Abstract Background Clear cell renal cell carcinoma (ccRCC) is characterized by a highly heterogeneous tumor immune microenvironment. However, how tumor-intrinsic programs shape immune cell states remains incompletely understood. We aimed to identify multicellular programs (MCPs) linking tumor and immune compartments a...

Katsuhiro Ito, S. Kashima, Rishabh Rout et al. · 0 citations

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