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Author

Z. Zhuang

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Open access Oct 2026

ESR1 bridges GNGT1 to CLDN6 in promoting gastric cancer stemness and development

Gastric cancer (GC) remains a major global health burden, and the molecular determinants driving its progression are incompletely understood. In the present study, G protein subunit gamma transducin 1 (GNGT1) was identified as a clinically relevant oncogenic driver that promotes GC growth, stemness, and metastatic...

Yan Zhang, Si-Si Chen, Z. Zhuang · 0 citations
Clinical trial Open access Aug 2026

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib demonstrated superior efficacy to gefitinib with a similar tolerability profile in the first-line treatment of EGFR-mutated advanced NSCLC with common and uncommon EGFR-activating mutations.

Jia Yu, Anwen Xiong, Qi-Ming Wang et al. · 0 citations
Aug 2026

Circ_PRKCA Drove NSCLC Progression via SRSF1/HIF-1A/PKM2 Axis-Mediated Glycolytic Reprogramming.

The data suggest that circPRKCA may act as a scaffold for RNA-binding proteins (RBPs), potentially facilitating the recruitment of SRSF1 to HIF-1A mRNA, which appeared to correlate with increased HIF-1A stability, and reveal novel diagnostic biomarkers and therapeutic strategies for NSCLC.

Hai-Ting Chen, Xing-Xing Jin, Leilei Tao et al. · 0 citations

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