Zachary R. Baker

Prophage-encoding engineered bacteria enable prophylactic lytic phage therapy for enteric infection in mice.

Phage therapy is a promising antibacterial approach but it has limited efficacy against enteric bacterial infections, such as Salmonella enterica Typhimurium (STm). Here we hypothesized that establishing high concentrations of a pathogen-targeting phage in the gut before infection would prophylactically protect against...