Zachary S. Clark

Carbohydrate-Directed Labeling Probes for UV-Independent Chemoproteomic Profiling of Carbohydrate-Protein Interactions.

Weak and transient carbohydrate-protein interactions hinder the detection of carbohydrate-binding proteins (CBPs) in native settings. Here, we introduce carbohydrate-directed labeling probes (CDLPs), modular ligand-directed covalent probes composed of a glycan ligand, an acyl-transfer electrophile, and a distal azide h...