Zachary Wu

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry

Directed evolution and machine-learning-assisted evolution have transformed biocatalysis by enabling rapid optimisation of catalytic performance within compatible protein scaffolds. In parallel, advances in deep-learning-driven de novo protein design have expanded accessible protein architectural space, enabling the ge...