TARGETING BACTERIAL BIOFILMS-MEDIATED DYSREGULATION OF IMMUNE CHECKPOINTS: A NEW DIMENSION FOR ANTI-PATHOGENIC IMMUNOTHERAPY
Bacterial infections associated with biofilms continue to be significant clinical problem due to their antibiotic resistance and immunosuppressive capabilities. The recent evidence indicates that the immune checkpoint signaling (PD-1/PD-L1) is involved in the immune impairment in chronic biofilm infections. The study e...