Zaynoun Attieh

Total Synthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic

A convergent total synthesis of the proposed structure of pre-rhabdobranin B revealed a stereochemical misassignment at the N-terminal arginine residue, which validate resistance-gene-guided discovery in Gram-negative symbionts as a strategy for uncovering cryptic antibiotics and identify rhabdobranin as a promising sc...