Bile acids, as cholesterol metabolites, orchestrate a regulatory network with mitochondrial quality control (MQC) through nuclear receptor FXR, membrane receptor TGR5, and other signaling molecules, modulating mitochondrial biogenesis, dynamic equilibrium, selective autophagy, and redox homeostasis. TGR5 promotes PGC-1...
Xue-Ru Jia, Ze-Han Zhang, Xiao-Yu Lin et al.· Pharmacological Research· 0 citations
This work leveraged two-sample Mendelian randomization to systematically evaluate the causal effects of 179 plasma lipid species and 4,907 plasma proteins on anxiety disorders, using two large-scale independent GWAS datasets for replication and identified three lipids with robust causal effects.
Jiahui He, Ze-Han Zhang, Yanan Wang et al.· Behavioural Brain Research· 0 citations
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