Author

Ze-Hao Hong

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Review Open access Aug 2026

Post-translational modification-governed immune states in cancer immunity: Biomarker implications for checkpoint competence, tumor visibility and immunotherapy resistance (Review)

By organizing PTM biology around measurable state variables rather than modification class alone, the present review provides a phase-aware translational framework for candidate biomarker discovery, fit-for-purpose validation, constraint-guided stratification, and therapeutic prioritization in cancer immunotherapy.

Jing-Hao Pan, Bo-Yang Li, Ruo-Nan Lin et al. · International Journal of Onc... · 1 citation

Review Sep 2026

Metabolic and epigenetic plasticity of tumor-associated macrophages shapes immunosuppressive outputs and immune checkpoint response.

Immune checkpoint blockade (ICB) has transformed cancer therapy, but durable responses are frequently limited by tumor microenvironment-driven resistance. Tumor-associated macrophages (TAMs) are central mediators of this process because they sense metabolic stress and convert it into immunosuppressive programs that res...

Jing-Hao Pan, Bo-Yang Li, Lucy Yue Lau et al. · Biochimica et biophysica act... · 0 citations