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Ze-Hui Guo

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Sep 2026

Substrate Channeling on Bienzyme Assembly Significantly Enhances Cascade Biocatalysis of Ene Reductase and Aldehyde Dehydrogenase at High Substrate Concentrations

Multienzyme cascades enable efficient synthesis of value-added chemicals by coupling sequential biotransformations. In the ene reductase (OYE)–aldehyde dehydrogenase (ALDH) cascade for chiral α-substituted carboxylic acids, accumulation of the saturated aldehyde intermediate inhibits OYE and thereby limits cascade pe...

Ze-Hui Guo, Yu Meng, Yan Sun · 0 citations

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