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Review Open access Sep 2026

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity. The review cov...

Wen-Guang Chen, Bao-Xiu Yi, Zhan-Kun Wang et al. · 0 citations
Review Open access Oct 2026

Mechanisms and Clinical Translational Prospects of the Microbiota–Gut–Lung Axis in Connective Tissue Disease-Associated Interstitial Lung Disease

Connective tissue disease-associated interstitial lung disease (CTD-ILD) is one of the most severe pulmonary complications of connective tissue diseases, featuring rapid progression and heterogeneous prognosis. Early recognition and prognostic prediction remain substantial clinical challenges. Accumulating evidence ind...

Jun-Xia Hu, Shi-Wen Ke, Li-Sha Mo et al. · 0 citations

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