Ze-Tong Zheng

LAPTM4B in tumor immune evasion: lysosomal autophagy, metabolic adaptation, and therapeutic resistance

Tumor immune evasion is shaped not only by canonical immune checkpoints but also by lysosomal stress adaptation, autophagy, metabolic remodeling, and therapy-induced survival programs within malignant cells. Lysosomal-associated protein transmembrane 4 beta (LAPTM4B), an oncogenic lysosomal transmembrane protein, h...