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Open access Oct 2026

Taurine metabolism-related genes IL1B and ALPL orchestrate gut–microbiota–immune crosstalk in granulosa lutein cells in PCOS

Polycystic ovary syndrome (PCOS) is a systemic disorder characterized by metabolic dysfunction and chronic inflammation. Although gut microbiota dysbiosis has been implicated in PCOS, the mechanisms linking gut microbiota-derived metabolites to host immune dysregulation through taurine metabolism-related genes (T...

Yun Bai, Wei-Yuan Li, Xiao-Ping Liu et al. · 0 citations
Open access Sep 2026

Integrated follicular fluid multi-omics identifies steroidogenic dysregulation and a candidate SHBG-associated rescue framework in poor ovarian response

Introduction Poor ovarian response (POR) remains a major obstacle in assisted reproductive technology, yet the follicular microenvironmental determinants of impaired ovarian sensitivity are poorly understood. This study aimed to characterize the multi_omics landscape of the follicular fluid in POR and to explore potent...

Run-Zi Zheng, Yan Jiao, Jia-Peng Liu et al. · 0 citations

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