TOP2A Overexpression as a Prognostic Biomarker in High-Grade Meningioma: An Integrated Single-Cell and Bulk Transcriptomic Study
By integrating transcriptional overexpression with copy-number gain, this study identifies TOP2A mRNA and protein overexpression as a prognostic biomarker in high-grade meningioma and shows that focal TOP2A copy-number gain is enriched in high-grade tumors and concordant with TOP2A expression.