A regulatory adaptor for RAD51's AAA+ unfoldase promotes homologous recombination-mediated DNA repair and genome stability.
DNA double-strand breaks, including those arising from DNA interstrand crosslinks, are highly cytotoxic forms of DNA damage. Their precise repair by homologous recombination (HR) is essential for maintaining genomic stability. During HR, timely disassembly of the core machinery, RAD51 nucleoprotein filaments, is critic...