Author

Zeng-Jun Lu

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Open access Sep 2026

Generation and characterization of a PRRSV-2 DIVA marker virus by deletion of a novel epitope in the nucleocapsid protein

The feasibility of developing a PRRSV DIVA vaccine through targeted modification of an N protein epitope is demonstrated, providing a potential strategy to facilitate PRRS control and suggests that combining the recombinant virus with cELISA diagnostic tests allows accurate differentiation between vaccinated and wild-t...

Ji-Wen Sun, Jian Wang, Kun Li et al. · Journal of Virology · 0 citations

Open access Aug 2026

Genome-wide CRISPR screen identifies RNF24 as a critical host factor for foot-and-mouth disease virus entry

An unbiased genome-wide CRISPR/Cas9 knockout screening using porcine cells reveals a ubiquitin-dependent RNF24-LPXN regulatory axis that supports FMDV entry, highlights the role of non-degradative ubiquitination in viral pathogenesis, and proposes this interface as a potential target for antiviral intervention.

Jin-Yan Zhang, Hai-Long Liu, Jian Du et al. · Frontiers in Cell and Develo... · 0 citations