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Zeng-Ming Zhang

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Open access Oct 2026

Distinct genetic perturbations at the endogenous Atf4 locus uncouple polyadenylation loss from transcriptional readthrough

Transcription termination by RNA polymerase II (RNAPII) is coupled to co-transcriptional cleavage and polyadenylation directed by the canonical AAUAAA polyadenylation signal (PAS). However, the in vivo requirement of the canonical PAS for termination fidelity remains unclear. Here, we dissect PAS-dependent terminat...

Zeng-Ming Zhang, Tong-Bin Wu, Ze-Yu Chen et al. · 0 citations

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