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Author

Zhang-Jian Huang

3 papers indexed here

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Sep 2026

A Platinum(IV)-Ursolic Acid Conjugate Overcomes Cisplatin Resistance in Ovarian Cancer by Targeting XPO1 and PARP1

Cisplatin is a cornerstone chemotherapeutic for ovarian cancer, yet its clinical utility is constrained by severe systemic toxicity and acquired drug resistance. Here we report a novel platinum (IV) prodrug, US-CIS-OH, generated by conjugating cisplatin with ursolic acid (UA), a natural pentacyclic triterpenoid with...

Zi-Qi Pan, Zhi-Ying Qin, Zi-Yu Qian et al. · 0 citations
Review Open access Sep 2026

BeyondTACs: Chemical Editing of Posttranslational Modifications (PTMs) for Therapeutic Intervention.

Protein posttranslational modifications (PTMs) build up the diversity and complexity of the proteome, and their dysregulation is intrinsically linked to various diseases. The study of PTMs has profoundly broadened the scope of therapeutic target discovery. Building upon the success of PROTACs, this heterobifunctional p...

Chen Zhang, Hui Ye, Yi-Hua Zhang et al. · 0 citations
Review Jul 2026

Clinical Challenges in Echinococcosis Treatment and Frontiers in New Drug Development: Current Status and Future Outlook.

This review systematically assesses the progress, core strengths, and key translational barriers of four mainstream anti-echinococcosis drug development avenues over the past five years to provide a crucial theoretical foundation and practical reference for precise disease control, optimized clinical strategies, and th...

Lin Wang, Zhengsheng Yan, Si Chen et al. · 0 citations

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