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Zhang-Qin Yang

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Review Open access Sep 2026

The Double-Edged Sentinel: cGAS-STING as a Context-Dependent Regulator of Microglial Senescence and Neuronal Genotoxic Stress in Neurodegeneration.

BACKGROUND Neurodegenerative diseases may continue to progress even when a pathogenic protein aggregate is reduced, suggesting that downstream inflammatory and genotoxic circuits can become partly autonomous. This narrative review examines cGAS-STING as a context-dependent regulator of DNA-stress responses in the agein...

Chun-Fang Zhang, Zhang-Qin Yang · 0 citations

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