Zhang Yanan

Hippocampal Remodeling in Chronic Pain: Structural, Functional, Cellular, Metabolic, and Molecular Mechanisms and Therapeutic Perspectives.

This review systematically synthesizes current evidence on hippocampal alterations in chronic pain across multiple levels and proposes a multiscale integrative framework in which synaptic imbalance, neuroimmune activation, and neurotrophic dysregulation interact to drive hippocampal dysfunction, forming a bidirectional loop that links pain, emotion, and cognition.