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Zhao-Wei Cai

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Sep 2026

FABP3 regulates vascular remodeling and endothelial-mesenchymal transition through NF-κB activation in aged mice fed a high-fat diet.

BACKGROUND Aging and obesity synergistically promote pathological vascular remodeling mediated by endothelial-mesenchymal transition (EndMT). Fatty acid-binding protein 3 (FABP3) maintains fatty acid homeostasis and cardiovascular function; however, its role in EndMT-driven vascular remodeling under combined aging and...

Wen-Jing Chen, Dong-Ying Lv, Yu-Jie Ren et al. · 0 citations
Open access Sep 2026

Smilax glabra flavonoids ameliorate non-alcoholic steatohepatitis by regulating PKM2-dependent glycolysis and suppressing AIM2 inflammasome activation

Background Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver disease characterized by hepatic steatosis, persistent inflammation and progressive liver damage. Smilax glabra flavonoids (SGF), the major bioactive constituents of Smilax glabra Roxb., exhibit potent antioxidant and anti-inflammatory activiti...

Zi-Yao Pang, Yue Ding, Lei Hu et al. · 0 citations

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