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Author

Zhao-Xing Dong

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Open access Oct 2026

Targeting senescence-associated fibrotic signatures identifies syringin as an effective modulator of the ATR/CHK1-p53 axis in idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease closely associated with aging, yet the contribution of cellular senescence to fibrotic remodeling and its therapeutic implications remain incompletely understood. Syringin, a phenylpropanoid glycoside derived from Acanthopanax sent...

Yu-Yan Wang, Guang-Hui Yin, Mi-Xing Niu et al. · 0 citations
Open access Sep 2026

circHIPK3 promotes pro-fibrotic epithelial reprogramming via the miR-29a-3p/SPARC axis with associated enhancement of TGF-β/SMAD signaling

Background Idiopathic pulmonary fibrosis (IPF) is fatal with limited treatments. circHIPK3 is upregulated in fibrotic lungs, but its role in lung epithelial cells and connection to TGF-β/SMAD signaling are unclear. Methods We used TGF-β1-stimulated lung epithelial cells (A549, BEAS-2B) and a bleomycin-induced mouse mod...

Ying Zhou, Yi-Xin Huang, Jiang-Po Ma et al. · 0 citations

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