Author

Zhao Zhang

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Open access Sep 2026

Permissive but not causative: layer-specific LHCGR alterations in ovarian aging

A trafficking hypothesis rather than a demonstrated mechanism is advanced: a transcriptomic profile compatible with premature luteinization may be superimposed on disordered stage-dependent surface presentation and motivates prospective evaluation of biomarkers for stratified LH supplementation in assisted reproductive...

Hong-Bo Wu, Zhao Zhang, Li-Yan Huang et al. · npj Aging · 0 citations

Review Open access Jul 2026

Theca cells: active orchestrators of ovarian aging.

This review repositions theca cells as active, bidirectionally regulated participants in ovarian aging-integral to, rather than upstream of, the oocyte-granulosa-theca unit, and proposes theca-specific biomarkers and targeted interventions as priorities for future translational research.

Hong-Bo Wu, Zhao Zhang, Qian-Yi Huang et al. · Reproductive Biology and End... · 0 citations