Author

Zhao-Lin Chen

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Sep 2026

A Ubiquinone-Reactive Pt(IV) Prodrug Perturbs Mitochondrial Metabolism for Selective Tumor Suppression.

Pt(IV) prodrugs offer a versatile platform for the design of platinum-based antitumor drugs; yet utilizing axial ligands to actively modulate tumor bioenergetics has been less investigated. Herein, we report a mitochondria-directed Pt(IV) prodrug, LA-Pt(IV), in which lipoic acid (LA) serves as a metabolite-reactive axi...

Yi Dai, Wen-Xin Yu, Yi-Chen Yin et al. · ACS Applied Bio Materials · 0 citations

Sep 2026

Discovery of oxazole-capped 4-phenoxypiperidine CSF1R type II inhibitors with potent in vivo anti-rheumatoid arthritis activity.

Colony-stimulating factor 1 receptor (CSF-1R) is a key target for regulating macrophage function and mediating the inflammatory response. Blocking CSF-1/CSF-1R signaling pathway and its downstream AKT cascade can effectively inhibit the release of downstream proinflammatory cytokines, which provides a promising therape...

Zhen-Ni Xia, Xue-Jian Zhou, Zhao-Hui Guo et al. · Bioorganic chemistry (Print) · 0 citations

Open access Jul 2026

Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma

It is suggested that glycolytic activity is closely associated with both drug resistance and clinical prognosis in LUAD, and the proposed integrative model holds promise for enhancing precision treatment decision-making through optimized risk assessment and rational selection of chemotherapeutic regimens.

Qian Zheng, Yunxiao Liu, Tianli Li et al. · Frontiers in Oncology · 0 citations