Open access
Jul 2026
LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming
It is shown that LSD1 knockdown has opposing, subtype-specific effects on chemotherapeutic responses: it sensitized RSK-subtype cells to chemotherapy but induced resistance in KRAS-subtype cells, revealing mitochondrial dysfunction and defective mitophagy as hallmarks distinguishing KRAS- from RSK-subtype PDAC.
Zhe-Fang Wang, Qiu Huang, Jian-Gang Zhao et al.
· Cell Death and Disease · 1 citation