Bile acids (BAs) are amphiphilic steroid acids that exert a broad range of physiological effects-including the regulation of metabolism, immune responses, and inflammatory processes-through activation of specific receptors such as the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5). The...
Hong-Xia Zhu, He-Ming Chen, Qing-Jun Gong et al.· Medicinal research reviews (...· 0 citations
The findings identify CTHRC1 as a novel mediator in the bone microenvironment, providing a potential therapeutic target for inhibiting the occurrence and progression of PCa bone metastasis.
Tao Xie, Tian-Ming Peng, Qu Li et al.· Oncogene· 0 citations
Despite the research progress of the past decades, the prognosis for pancreatic ductal adenocarcinoma remains poor. Identifying novel targets and exploring the underlying mechanisms is therefore of great importance. ELF3 (E74 like ETS transcription factor 3) is a member of the E-twenty-six (ETS) family and previo...
Yu-Ru Shang, Pingping Zhang, Yanhui Yang et al.· Journal of Experimental &...· 0 citations
Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in coordinating inflammatory tone and redox balance. Itaconate, generated thr...
Jian-You Gu, Wen-Ying Zhang, Jun-Feng Zhang et al.· Signal Transduction and Targ...· 0 citations
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and contribute substantially to gastric cancer progression. However, the phenotypic and functional heterogeneity of CAFs in gastric cancer remains incompletely characterized. Here, we analyzed single-cell transcriptomic data from gast...
Yu-Sheng Luo, L. Zhong, Ke-An Mu et al.· Cancer Genetics· 0 citations
Current cancer treatment still relies largely on stage-specific diagnosis and relatively fixed therapeutic regimens, while diagnostic information, therapeutic intervention, and efficacy feedback are often separated across different time windows. This fragmentation limits the ability to meet the demands of precision and...
Xuan-Ming Mao, Ming-Yu Cui, Lu-Qi Cao et al.· Soft Science· 1 citation
Mechanistic evidence is provided supporting Ber as a potential modulator of mitochondrial dysfunction during sepsis-associated myocardial injury and mitochondrial regulation as a potential target for further investigation and highlights mitochondrial regulation as a potential target for further investigation.
Ze-Lin Li, Ji-Hong Liu, Qi Shen et al.· Pathology, Research and Prac...· 0 citations
A conceptual shift from conventional MDR models toward systemic adaptive resistance is proposed, and classical drug resistance, including drug uptake/efflux, compensatory pathway activation, and apoptosis evasion is reviewed.
Xiang Chen, Qin-Guo Huang, Ryan Li et al.· Pharmacology and Therapeutic...· 0 citations
This review outlines molecular, cellular, and microenvironmental adaptations in cancer RT that confer enhanced chemotherapy resistance in cancer cells surviving from ionizing radiation (IR), and summarizes mechanisms and emerging strategies for drug resistance in cancer RT.
Yang Chen, Chao-Yun Cai, Xiao-Cheng Xu et al.· Pharmacological Research· 0 citations
A comprehensive analysis of the molecular structure of ADCs, the pharmacological principles underlying their potent cytotoxic activity against MDR cancer cells, the genomic and transcriptomic biomarkers that guide ADC patient selection, and the emerging resistance mechanisms that will shape the next generation of promi...
Ryan Li, Xiang Chen, Qin-Guo Huang et al.· Cancer Letters· 0 citations
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