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Author

Zhen-Bao Liu

5 papers indexed here

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Oct 2026

Self-assembled ferric-shikonin-quercetin (FSQ) nanoparticles co-delivering R848 enable lactate reduction, ICD induction, and immune modulation in vitro.

To overcome inadequate tumor immunogenicity and the immunosuppressive tumor microenvironment, a self-assembled nanomedicine (R848@FSQ) is developed by coordinating the chemotherapeutic drugs shikonin (SHK) and quercetin (Qu) with Fe3 + to form a metal-phenolic network (MPN), and is simultaneously loaded with the immune...

Xing-Xing Peng, Qi-Wen Chen, Jing Chang et al. · 0 citations
Sep 2026

Inhalable mucus-penetrating and senescence-targeted nanoliposomes reverse senescence to overcome chemoresistance for enhanced lung cancer therapy.

Lung cancer therapy is severely hindered by the pulmonary mucus barrier and chemotherapy resistance driven by therapy-induced senescence (TIS) following DNA-damaging agents. Herein, we report an inhalable, mucus-penetrating nanoliposomes (DR@DPPC-Apt) engineered by incorporating an L1 cell adhesion molecule (L1CAM)-tar...

Yun-Qi Man, Yan-Fei Liu, Yong-Bo Liu et al. · 0 citations
Review Sep 2026

Bacterial metabolic-immune reprogramming in cancer: from living vectors to engineered biofactories.

Tumor immunotherapy has transformed modern oncology, yet its clinical efficacy against solid tumors remains severely restricted by complex physiological and immunosuppressive barriers. Distinct from passive delivery systems, live bacteria can actively navigate into hypoxic tumor cores and intrinsically modulate local i...

Jun-Jie Wu, Li-Shang Xu, Qi-Wen Chen et al. · 0 citations
Review Sep 2026

Cellular and In Vivo Fate of DNA Nanostructures.

This review provides a conceptual framework for navigating the critical design trade-offs inherent in engineering DNA nanostructures for in vivo application and offers forward-looking perspectives for the development of DNA-based nanocarriers.

Jun-Gang Ren, Qian Wu, Lu-Ke P. Lee et al. · 0 citations
Review Sep 2026

Multidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics.

This review systematically maps the molecular architecture of the senescent-cell heterogeneity, off-target toxicity, and the lack of standardized biomarkers, and provides a framework for developing precision strategies to detect, modulate, or eliminate senescent cells in a context-appropriate manner.

Ze-Xiang Lv, Yan-Fei Liu, Yong-Bo Liu et al. · 0 citations

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