Zhen Chen

Antibody-Mimicking Nanocluster Ameliorates Osteoporosis in Preclinical Model

Osteoporosis occurs due to the synergistic effect of increased bone resorption and decreased bone formation. However, a therapeutic approach that can simultaneously inhibit osteoclastic resorption and promote osteogenic activity directly is still lacking. Growing evidence demonstrates the I-kappaB kinase beta (IKKβ)-...

Single-atom inhibition of oncogenic drivers through cysteine coordination