Zhen-Di Shi

Design, Synthesis, and Anti-Inflammatory Activity Evaluation of Novel thieno[2,3- d ]Pyrimidin-4(3 H )-One-Based NLRP3 Inflammasome Inhibitors

The NLRP3 inflammasome plays a critical role in the pathogenesis of inflammatory diseases and has emerged as a promising therapeutic target. Our preliminary studies revealed that istradefylline, an anti-Parkinsonian agent, exhibits moderate NLRP3 inhibitory activity. Furthermore, we optimized the structure and activi...