Zhen-Guo Zhang

Recent Advances in Primary Amine-Targeted Bioconjugation for Selective Protein Modification and Biomedical Applications

Primary amine-targeted bioconjugation connects proteins and other biomacromolecules with functional payloads for diagnosis and targeted therapy. However, conventional reagents such as N-hydroxysuccinimide esters often modify multiple surface lysines, producing heterogeneous conjugates with compromised activity and clin...