Zhen-Hai Chen

SADS-CoV Nsp1 hijacks proteasomal subunits to degrade IRF1.

Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) is an emerging porcine enteric coronavirus that causes severe diarrhea in piglets. Type III interferon (IFN) are crucial for intestinal antiviral defense, and the capacity of SADS-CoV to disrupt IFN-III responses is critical for its replication. This study found that...

Commandeering the controller: The ubiquitin-proteasome tug-of-war between coronavirus and host.

Characterization and pathogenicity of single-farm-isolated PRRSV 1 and PRRSV 2 strain in China

The evidence of PRRSV 1 and PRRSV 2 concurrent circulation in the single sow farm in China is provided, which highlights the ongoing evolution of both Chinese PRRSV species and underscores the urgent need for enhanced surveillance and updated control strategies.