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A monotonic increasing association of the metal mixture with both BWZ and LGA, with the trend significant at lower-to-moderate concentrations is shown, whereas no significant associations were observed for SGA.
BACKGROUND Prenatal exposure to metal mixtures may influence newborn birth size, but the underlying metabolic mechanisms remain unclear. This study aimed to evaluate the associations of 19 individual maternal metals and metal mixtures during pregnancy with birth size indicators, specifically birth weight z score (BWZ)...
Early-pregnancy PFAS exposure was associated with impaired fetal growth and altered amino acid and lipid metabolism may underlie these associations, and metabolomics data suggested several exploratory candidate intermediate metabolite features that may be involved in the associations.
It is suggested that prenatal PFAS exposure is associated with reduced BW-z, particularly among female infants, and that altered fasting glucose may represent one possible, but not primary, pathway linking selected PFAS to fetal growth.
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