The conceptual framework of metabolite-driven protein modifications is summarized, established marks are compared, and remaining questions surrounding pyruvylation chemistry, enzyme and substrate specificity, reader mechanisms, compartmentalization, detection strategies, physiological relevance, and potential immunopha...
Zi-Ye Zhang, Ming-Ze Xu, Sen Zhang et al.· Frontiers in Immunology· 0 citations
Traditional PK/PD targets (Ctrough and AUC/MIC) did not correlate with clinical efficacy in this real-world setting, and AUC was a better predictor of nephrotoxicity than Ctrough, and female gender was an independent risk factor for vancomycin-associated anemia.
Nai-Ju Zhang, Yi Li, Long-Yun Chen et al.· Frontiers in Pharmacology· 0 citations
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