Glioblastoma (GBM) is the most aggressive primary tumor of the brain, characterized by extensive intratumor heterogeneity, and exhibits inevitable recurrence despite conventional therapy. This study investigates the immunosuppressive mechanisms underlying GBM recurrence following temozolomide (TMZ) therapy, with a spec...
Zhen-Kun Yang, Jie Li, Da-Xing Xu et al.· International Immunopharmaco...· 0 citations
Abstract Background Connective tissue diseases (CTDs) frequently involve the lungs, with CTD-associated interstitial lung disease (CTD-ILD) representing a leading cause of morbidity and mortality, yet the immunopathological mechanisms remain incompletely defined. This study characterized immune profiles in CTD-ILD and...
Zhen-Kun Yang, Hui-Xing Li, C. Qin et al.· Annals medicus· 0 citations
GPRC5B is a macrophage-enriched, PMO-associated candidate identified through integrated transcriptomic analyses and supported by preliminary functional experiments, suggesting that GPRC5B may participate in macrophage-related alterations in PMO and warrant further mechanistic and translational investigation.
Shi-Zhou Zhao, Yi-Xing Yang, Jiao Meng et al.· Frontiers in Immunology· 0 citations
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